中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2006, 18(1): 80-
组蛋白去乙酰化酶抑制剂(HDAIs)对异染色质的作用
张 伟1*, 明镇寰2
1温州医学院医学部,温州325035;2浙江大学生命科学学院,杭州 310012
摘 要:组蛋白乙酰化和去乙酰化可调节染色体的多种功能,例如基因表达和染色体分离等。研究发现,组蛋白去乙酰化酶抑制剂(histone deacetylase inhibitors, HDACIs)可诱导分化、生长阻断和肿瘤细胞凋亡,目前HDACIs正作为抗肿瘤药物进行临床试验,在肿瘤治疗中显示出具有较好的应用前景。然而,人们对于HDACIs在生物体内是如何发挥作用以及不同类型细胞为何会有不同的应答途径却关注甚少。本综述通过讨论HDACIs对周期和非周期细胞中组蛋白去乙酰化酶的抑制结果,来阐明组蛋白乙酰化模式的动力学特征,特别是对基因组异染色质的作用。
关键词:组蛋白乙酰化和去乙酰化;HDACIs;异染色质;有丝分裂
 
The effects of histone deacetylase inhibitors on heterochromatin
ZHANG Wei1*, MING Zhen-Huan2
1 Wenzhou Medical College, Wenzhou 325035, China; 2 School of Life Sciences, Zhejiang University, Hangzhou 310012, China
Abstract: Histone acetylation and deacetylation can regulate many chromosome functions, such as gene expression and chromosome segregation. Histone deacetylase inhibitors(HDACIs)induce growth arrest, differentiation and apoptosis of cancer cells, and are now undergoing clinical trials as anti-tumor agents and display attractive prospect in cancer therapy. However, little attention has been paid to how HDACIs function in these biological settings and why different cells respond in different ways. In this review, we discussed the consequences of inhibiting histone deacetylases in cycling versus non-cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome.
Key words: histone acetylation and deacetylation;HDACIs;heterochromatin;mitosis
 
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