中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2006, 18(1): 67-
药物基因组学对癌症化疗的启示
周 喆1,岳利多2,覃文新2*
1华东理工大学生物工程学院,上海200237;2上海交通大学医学院上海市肿瘤研究所癌基因及相关基因国家重点实验室,上海 200032
摘 要:药物基因组学的研究任务是阐明个体差异的遗传基础,并利用这些遗传信息来预测药物的疗效、毒性和安全性。绝大多数的癌症化疗药物在治疗效果及正常组织毒性上的个体差异一直广为关注。不仅诸多临床因素(如年龄、性别、饮食、药物相互作用等)与药物反应和治疗效果有关,而且药物分布(转运和代谢)和药物靶标的遗传变异同样可导致癌症治疗上的差异。本篇综述主要讨论当前和将来药物基因组学在临床癌症治疗和抗癌药物研制方面的应用。
关键词:药物基因组学;遗传变异;癌症治疗;抗癌药物研发
 
Pharmacogenomics: implication for cancer chemotherapy
ZHOU Zhe1, YUE Li-Duo2, QIN Wen-Xin2*
1 College of Biotechnology, East China University of Science and Technology, Shanghai 200237, China; 2 National Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University Medical School, Shanghai 200032, Chin
Abstract:  Pharmacogenomic studies aim to elucidate the genetic bases for interindividual differences and to use such genetic information to predict the safety, toxicity, and/or efficacy of drugs. Interindividual differences in tumor response and normal tissue toxicities are consistently observed with most chemotherapeutic agents or regimens. While many clinical variables have been associated with drug responses (e.g., age, gender, diet, drug-drug interactions), inherited variations in drug disposition (transport and metabolism) genes and drug target genes also likely contribute to the observed variability in treatment outcome. This review discusses the current and future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
Key words:  pharmacogenomics; genetic variations; cancer therapy; cancer drug development
 
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