中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2006, 18(1): 62-
NKT细胞在抗肿瘤免疫中的作用及其机制
杨 洁1,2,范华骅1*,章 平2,高 峰1
1上海市血液中心血液工程研究室,上海 200051; 2华东师范大学生命科学学院分子免疫研究室,上海 200062
摘 要:NKT细胞是免疫细胞中一类具有NK细胞特定标志的T细胞亚群,经活化,既可直接作为抗肿瘤效应细胞发挥杀伤作用,又能通过激活其他免疫效应细胞,如NK细胞,间接实现抗肿瘤作用。NKT细胞在抗肿瘤免疫、获得性免疫应答及免疫调节中起着重要作用。
关键词:NKT细胞;抗肿瘤作用;抗肿瘤机制
 
Functional role of natural killer T cells and their mechanisms in anti-tumor immunity
YANG Jie1,2, FAN Hua-Hua1*, ZHANG Ping2,GAO Feng1
1 Shanghai (Red cross) Blood Center,Laboratory for Blood Engineering, Shanghai 200051, China; 2 Laboratory of Immunology, School of Life Sciences, East China Normal University, Shanghai 200062, China
Abstract: Natural killer T (NKT) cells are a population of T cells that share some characteristics with natural killer (NK) cells. After activated, NKT cells can kill tumors directly as the anti-tumor effectors and they can also activate other cell types, such as NK cells, to mediate anti-tumor effects indirectly. NKT cells play an important role in anti-tumor immunity, adaptive immune responses and immunoregulation.
Key Words: NKT cells; anti-tumor function; anti-tumor mechanism
 
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