中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2006, 18(1): 51-
NMDA受体在痛觉过敏中的作用
陈 菲,方步武*
天津医科大学药理教研室,天津 300070
摘 要:N-甲基-D-天冬氨酸受体(NMDA受体)是中枢神经系统中兴奋性递质谷氨酸受体的一种类型,属于离子型受体。它涉及了体内许多复杂的生理和病理过程,包括wind-up、中枢敏化、长时程增强、外周敏化和内脏疼痛、细胞坏死和凋亡,除此以外,还参与了痛觉过敏的产生和维持。对NMDA受体在痛觉过敏中作用的探讨为研发新一代的镇痛药提供了广阔的思路和前景。
关键词:N-甲基-D-天冬氨酸受体;痛觉过敏;镇痛
 
Effects of NMDA receptors on hyperalgesia
CHEN Fei, FANG Bu-Wu*
Department of Pharmacology, Tianjin Medical University, Tianjin 300070, China
Abstract: NMDA receptors are a subtype of excitatory transmitters-glutamate receptor in the central nervous system. They belong to ionotropic receptors and play an important role in many complex physiological and pathological processes, including wind-up, central sensitization, long-term potentiation, peripheral sensitization, visceral pain, cellular necrosis and apoptosis, as well as induction and maintenance of the hyperalgesia. Study on effects of NMDA receptors on hyperalgesia provides a wide strategy and prosperity for a novel class of analgesics.
Key words: NMDA receptors; hyperalgesia; analgesia
 
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