中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2006, 18(2): 133-
去乙酰化酶Sirtuin研究进展
蔡群芳,周 鹏*
中国热带农业科学院热带生物技术研究所热带作物生物技术国家重点实验室,海口 571101
摘 要:依赖于NAD+的去乙酰化酶Sirtuin对细胞的存活、衰老、凋亡等生理活动的调节起到十分重要的作用。Sirtuin系统中的ySir2和SIRT1就目前来说是研究得较为透彻的两个成员。ySir2参与了酵母的交配型基因沉默、端粒的沉默、rDNA重复序列的沉默以及细胞寿命等生理功能。人类SIRT1在细胞存活与代谢等过程中也起到调节作用。本文对Sirtuin的结构、作用机制、底物特异性、影响因子及其功能作了综述。
关键词:组蛋白去乙酰化酶;NAD;沉默信息调节因子;SIRT1
 
The research development of deacetylase (Sirtuin)
CAI Qun-Fang, ZHOU Peng*
State Key Biotechnology Laboratory for Tropical Crops, Institute of Bioscience and Biotechnology, CATAS, Haikou 571101,China
Abstract: The silent information regulator protein(Sir2) and its homologs(collectively known as Sirtuins) ,NAD+-dependent deacetylase enzymes, play an important role in physiological regulation, such as the survival,aging and apoptosis of cell. ySir2 is a member of the Sirtuin family, and the studies show it acts on the silencing of mating-type loci, telomeric DNA regions, ribosomal DNA repetition sequence and cellular aging. Another member, human SIRT1 also plays a part in regulation of cell survival and metabolism. In this review, we summarize the structure of Sirtuin and its function on gene silencing, metabolism and aging , and also discuss its molecular mechanism, substrate specificity, influence factor.
Key words: histone deacetylase; NAD; silent information regulator; SIRT1
 
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