中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2006, 18(3): 261-
mTOR信号途径与肿瘤
郑 杰
东南大学基础医学院病理与病理生理学系分子病理研究所,南京 210009
摘 要:mTOR信号途径是最近新出现的细胞内重要信号途径,该途径在进化上高度保守,主要通过控制蛋白合成来调节细胞生长。现发现人体某些错构瘤综合征和恶性肿瘤存在mTOR信号途径的异常激活,雷帕霉素及其衍生物是mTOR信号特异性的抑制剂。这些新发现对了解细胞的生长调控和肿瘤的靶向性治疗具有重要意义。
关键词:mTOR;雷帕霉素;错构瘤综合征;肿瘤
 
mTOR signaling pathway and cancer
ZHENG Jie
Institute of Molecular Pathology, School of Basic Medical Science, Southeast University, Nanjing 210009, China
Abstract: mTOR signaling pathway recently emerges from horizons. mTOR pathway is conservative in evolution and controls the cell growth via protein synthesis. The dysregulation of mTOR pathway is recognized to be associated with several hamartoma syndromes and cancers. Rapamycin and its derivatives selectively inhibit mTOR kinase activity. These new findings are very important  in regulations of the cell growth and cancer targeting therapy.
Key words: mTOR; rapamycin; hamartoma; cancer
 
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