中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2006, 18(3): 247-
Caspases抑制剂的研究进展
陈益华1,2,张华杰1,2,南发俊1*
1中国科学院上海生命科学研究院药物研究所,上海 201203;2中国科学院研究生院,北京100049
摘 要:目前证明Caspases蛋白酶家族在细胞凋亡的过程中起关键作用,因此也就成为药物发现的潜在靶点。Caspases抑制剂被认为是治疗细胞过度凋亡引起的相关疾病的有效手段。本文着重介绍了近些年来发展的Caspases抑制剂,特别是那些处于临床或接近临床阶段的候选药物。
关键词:细胞凋亡;Caspases;抑制剂
 
Progress in Caspases inhibitors research
CHEN Yi-Hua1,2, ZHANG Hua-Jie1,2, NAN Fa-Jun1*
1 Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China; 2 Graduate School of CAS, Beijing 100049, China
Abstract: The Caspases protease family has proved to play a pivotal role in the process of apoptosis,and is consequently potential target for drug discovery. Inhibitors of these Caspases are believed to be a valuable therapeutic method against disease involving abnormally upregulated apoptosis. Herein Caspase inhibitors developed recently , candidate drugs in clinical or pre-clinical were reviewed.
Key words: apoptosis; Caspases; inhibitor
 
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