中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2006, 18(3): 244-
CD8+ T细胞在多发性硬化中的致病性作用
梅云华, 徐凌云*
上海交通大学医学院 上海市免疫学研究所,中国科学院上海生命科学研究院/上海交通大学医学院 健康科学中心,上海 200025
摘 要:多发性硬化是T细胞介导的自身免疫性疾病。先前对它的研究大多集中在CD4+ T细胞的致病和调节性作用上,但是,近几年来越来越多的证据表明CD8+ T细胞也参与多发性硬化的病理损伤过程。CD8+ T细胞存在于MS病灶部位,髓鞘抗原特异性CD8+ T细胞也从MS患者的血液和脑脊液中分离得到,CD8+ T细胞通过直接杀伤或释放细胞因子和趋化因子等间接参与MS的病理过程。本文就近几年关于CD8+ T细胞在多发性硬化中的致病性作用的研究进展予以介绍。
关键词:CD8+ T细胞;CD4+ T细胞;多发性硬化;实验性自身反应性脑脊髓炎
 
The pathogenic roles of CD8+ T cells in multiple sclerosis
MEI Yun-Hua, XU Ling-Yun*
Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiaotong University School of Medicine
Abstract:  Multiple sclerosis (MS) is a T cell mediated autoimmune disease. Previous researches focus on the roles of CD4+ T cells, including the pathogenic and immune-regulatory roles. However, more and more evidences show that CD8+ T cells act as an important factor in the development of MS. CD8+ T cells were founded in the lesions of MS, and myelin antigen specific CD8+ T clones were isolated from MS patients. The autoreactive CD8+ T cells can damage target cells directly or amplify local inflammation through secreting cytokines and chemokines. Illustrating the roles of CD8+ T cells in MS will help us better understand the mechanisms of MS and find new prevention and therapeutic methods. 
Key wards:  CD8+ T cells; CD4+ T cells; multiple sclerosis; experimental autoimmune encephalomyelitis
 
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