中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2006, 18(4): 347-
干细胞壁龛功能的研究进展
张贺军,李 虹*,姚开泰
中南大学肿瘤研究所分子病理研究室,长沙410078
摘 要:随着干细胞研究的不断深入,人们愈来愈重视干细胞在机体组织中的居住环境——壁龛(niche)对干细胞的影响。干细胞的增殖分化行为受其所处微环境的影响。干细胞壁龛通过与干细胞之间的直接和(或)间接作用影响干细胞的命运。壁龛成分——壁龛细胞、细胞外基质和来源于壁龛细胞的可溶性因子在维持干细胞的特征、调控干细胞数量等方面发挥重要作用。
关键词:干细胞;壁龛;壁龛细胞;细胞外基质;肿瘤干细胞
 
The progress in studies on the functions of stem cell niche
ZHANG He-Jun, LI Hong*, YAO Kai-Tai
Laboratory of Tumor Molecular Pathology, Cancer Research Institute of Central South University, Changsha 410078, China
Abstract: Accompanying with further extension in the investigation of stem cells, the effects of niche that serves as their microenvironment in tissue on the functions of stem cells attract more and more attention. The proliferation and differentiation behaviors of stem cells are affected by their microenvironment in situ. The niche is composed of three components, including the localized niche cells, the extracellular matrix and soluble factors derived from niche cells. The components of niche could influence the stem-cell fate through direct and/or indirect contact between stem cells and niche. It plays important roles in maintaining the characteristics of stem cells, regulating the number of stem cells, etc.
Key words: stem cell; niche; niche cell; extracellular matrix; tumor stem cell
 
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