中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2006, 18(4): 341-
干细胞参与组织再生的一种机制:细胞融合
许 丹1,潘增祥1,蒋晓明2,蔡令波3,张艳丽1,丁晓麟1,王 锋1*
1南京农业大学动物科技学院,南京210095;2解放军第一七四医院生殖医学中心,厦门361003;3南京医科大学第一附属医院临床生殖医学中心,南京210029
摘 要:干细胞的研究开创了生命科学革命性的进程,人们将通过这一研究找到攻克诸如心血管疾病、神经退行性疾病、癌症、糖尿病等顽症的方法,因而这一工程又被称之为治疗人类疾病的“希望工程”。然而,人们对干细胞在组织修复和再生过程中的作用机制还知之甚少,目前认为干细胞横向分化能力及干细胞的融合是其主要的,也是最有争议的两种可能的机制。细胞融合在发育过程中是不可或缺的,如果人体内不能进行正常的细胞融合,将产生因精卵不融合造成的不孕、骨骼石化症、肌营养不良等疾病,而将干细胞融合应用于临床治疗的研究也日渐兴起。本文对干细胞参与组织再生和修复过程中与细胞融合相关的研究进展进行了综述,概述了干细胞融合的机制,分析了体内融合产生的原因及条件,以期为今后这方面的研究提供理论基础。
关键词:干细胞; 细胞融合; 损伤; 组织再生
 
Cell fusion : a mechanism of stem cells participating in tissue regeneration
XU Dan1, PAN Zeng-Xiang1, JIANG Xiao-Ming2, CAI Ling-Bo3, ZHANG Yan-Li1, DING Xiao-Lin1, WANG Feng1*
1 Center of Embryo Engineering and Technology, Nanjing Agricultural University, Nanjing 210095, China; 2 Reproduction Center of the No.174 Hospital of P.L.A, Xiamen 361003, China; 3 Human Clinical Reproductive Medicine Center, The First Affiliated Ho
Abstract: Stem cell research will contribute to a revolution in terms of how we treat cardiovascular disease, neurodegenerative disease, cancer, diabetes, and so far, so this project is called another "hope project" for the human diseases. But little is known about the mechanism that stem cells take part in the process of tissue regeneration, and the major possible mechanism should be trans-differetiation of stem cell and cell fusion. Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, abnormalities of cell-cell fusion might result in certain human diseases. For example, defects in sperm-ovum fusion represent a major cause of infertility. Certain muscle diseases, such as centronuclear myopathy and myotonic dystrophy, characterized by minute myofibers, may be partly due to defects in myoblast fusion. Furthermore, defects of placental trophoblast fusion lead to pregnancy complications such as preeclampsia, and defects in osteoclast fusion can cause bone abnormalities such as osteopetrosis. We reviewed the advance in understanding how stem cells act on tissue regeneration and repairation, summed up the mechanism of stem cell fusion.
Key words: stem cell; cell fusion; damage; tissue regeneration
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2952853 位访问者,欢迎!