中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2013, 25(10): 1036-1040
缓激肽B1受体与疼痛
晏燕花,付国良,洪炎国*
(福建师范大学生命科学学院 福建省发育与神经生物学重点实验室,福州 350108)
摘 要:缓激肽B1 受体(bradykinin 1 receptors, B1Rs) 是与Gq 蛋白相偶联的受体。正常状态下,B1R 除了在神经系统中( 如脊髓背角浅层和感觉神经节) 有少数表达外,其他机体组织中几乎不存在。在炎症或者神经受损的情况下,脊髓背角浅层和感觉神经节B1R 表达量大大上升,参与炎性疼痛和神经病理性疼痛的产生和维持。近年来的研究表明,B1R 在糖尿病性神经病理疼痛的发病中起着重要的作用。阻断B1R 能有效抑制糖尿病诱发的热痛觉过敏和冷觉及触觉超敏。此外,B1R 和癌症痛的发生也有密切关系,所以,对B1R 的研究可能会为治疗这些临床顽症提供新的靶点。
 
Bradykinin B1 receptors (B1R) and pain
YAN Yan-Hua, FU Guo-Liang, HONG Yan-Guo*
(Fujian Key Laboratory of Developmental and Neurobiology, College of Life Science,
    Fujian Normal University, Fuzhou 350108, China)
Abstract: Bradykinin 1 receptors (B1Rs) are coupled with Gq protein. In the normal condition, B1Rs are not expressed in the tissues except in the nervous system, such as superficial laminae of spinal dorsal horn and sensory ganglion. The expression of B1R in the spinal cord and DRG is greatly upregulated following inflammation and nerve injury, contributing to the induction and maintainence of inflammatory and neuropathic pain. Recently, studies have demonstrated that B1Rs play a pivotal role in diabetic neuropathic pain. Blockade of B1Rs can inhibit diabetes-induced heat hyperalgesia as well as cold and mechanical allodynia. In addition, B1Rs are also involved in cancer pain, so studies of B1Rs may provide a novel target for the treatment.
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2953218 位访问者,欢迎!