中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2013, 25(9): 891-896
L-肌肽影响血糖、血压、脂质代谢的相关研究进展
陶燕来1,吴 涛1,徐 亮1,富浩轩1,江倩茹1,钮亭亭2,傅正伟1*
(1 浙江工业大学生物与环境工程学院生理调控实验室,杭州 310014;2 上海体育学院,上海 200438)
摘 要: L- 肌肽(β- 丙氨酸-L- 组氨酸) 在哺乳动物骨骼肌中合成。L- 肌肽可影响自主神经系统相关的生理功能,通过影响所支配器官和组织的交感及副交感神经活性引起血压、血糖、食欲、脂质分解和产热等生理功能的变化。然而,由L- 肌肽引发的生理功能的变化又能因组胺H1、 H3 受体拮抗剂或生物钟主钟视交叉上核(SCN) 双侧损伤而解除。因此,主要概述在生物钟和组胺能神经的参与下,L- 肌肽通过自主神经途径调节血糖、血压、脂质分解和产热等生理机能的相关研究进展。
    关键词:L- 肌肽;交感神经;副交感神经;生物钟;组胺能神经
 
Advances on effects of L-carnosine on blood glucose, blood pressure
    and lipid metabolism
TAO Yan-Lai1, WU Tao1, XU Liang1, FU Hao-Xuan1, JIANG Qian-Ru1, NIU Ting-Ting2, FU Zheng-Wei1*
(1 College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China; 2 Shanghai University of Sport, Shanghai 200438, China)
    
Abstract: L-carnosine (β-alanyl-L-histidine) is synthesized in mammalian skeletal muscle. It is reported that L-carnosine affects physiological functions through the autonomic nerves system. In particular, L-carnosine affects the activity of sympathetic and parasympathetic nerves to further induce changes in blood pressure, blood glucose, appetite, lipolysis and thermogenesis. The changes in physiological functions mediated by L-carnosine are eliminated by histamine H1 or H3 receptor antagonists and bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN), a master circadian clock. This article briefly reviews the advances on the effects of L-carnosine on physiological functions such as blood glucose, blood pressure, lipolysis, and thermogenesis via autonomic nerves system and with the involvement of the circadian clock and histaminergic neurons.
    Key words: L-carnosine; sympathetic nerve; parasympathetic nerve; circadian clock; histaminergic neurons
 
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