中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2013, 25(6): 621-625
颗粒细胞在哺乳动物卵巢排卵过程中的调控作用
罗倩萍1,吴艳青1,2,张正红1,王正朝1*
(1 福建师范大学生命科学学院,福建省发育与神经生物学重点实验室,福州 35007;2 美国马里兰大学医学院,马里兰巴尔的摩 21201)
摘 要:在哺乳动物中,卵巢的主要生理功能包括排出成熟的卵母细胞与合成相关的生殖激素,而卵巢功能的维持和发挥依赖多种信使的传递和调控,其中颗粒细胞的増殖和成熟是关键一环。卵巢排卵是一个复杂的调控过程,除了需要具有发育能力的卵母细胞外,还需要通过许多信号分子的调控,如内分泌激素、免疫和代谢信号以及来自颗粒细胞分泌的各种调控因子。在前期研究的基础上,从生殖激素诱导的信号通路、排卵期的基因转录以及排卵相关的调控因子方面阐述哺乳动物卵巢的排卵过程,旨在为进一步理解卵巢排卵过程的分子调控机制以及不孕不育等卵巢疾病的治疗提供重要的研究方向和理论基础。
关键词:颗粒细胞;排卵;卵巢;哺乳动物
 
Regulatory effects of granulosa cells on ovarian ovulation in mammalians
LUO Qian-Ping1, WU Yan-Qing1,2, ZHANG Zheng-Hong1, WANG Zheng-Chao1*
(1 Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China; 2 School of Medicine, University of Maryland, Baltimore 21201, USA)
Abstract: In mammalians, the main physiological functions of the ovary contain releasing mature oocytes and synthesizing reproductive hormones, while the maintenance and effect of ovarian functions depend on the transfer and control of a variety of messengers, especially the proliferation and mature of granulosa cells. Ovarian ovulation is a complex regulating process, which not only requires developmentally competent oocytes, but also needs the regulation of many signal molecules, including endocrine hormones, immune and metabolic signals, as well as various regulating factors secreted by the granulosa cells. On the basis of our previous studies, the present review illustrated the mammalian ovary ovulation through the signaling pathway induced by reproductive hormones, the gene transcription during the ovulation and the regulating factors related to ovulation, in order to further understand the molecular regulating mechanisms of ovary ovulation and provide some important research direction and theoretical basis for
ovarian disease treatment like the infertility.
Key words: granulosa cell; ovulation; ovary; mammalian
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2952811 位访问者,欢迎!