中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2013, 25(5): 484-489
miR-128与恶性肿瘤关系的研究进展
李墨林1,沃璐璐2,付红勇1,方 龙1,李传刚3,舒晓宏4*
(1 大连医科大学病理生理学教研室,大连 116044; 2 大连医科大学2010级医疗系,大连 116044;3 大连医科大学附属二院泌尿外科,大连 116023;4 大连医科大学药学院,大连 116044)

摘 要:微小RNA (microRNA, miRNA)是一类长度为19~25个核苷酸、细胞内源性表达的单链非编码RNA,其通过转录后抑制或mRNA降解调控靶基因的表达,进一步调控靶蛋白参与的信号通路。微小RNA-128(miR-128)是一种在神经系统中高表达的miRNA,在神经系统的发育及正常生理功能的维持中发挥重要作用,其异常表达与神经胶质瘤、阿尔茨海默病等疾病密切相关。近年研究证实,miR-128与多种肿瘤细胞的增殖、分化、凋亡、侵袭和转移有关。miR-128已成为与肿瘤诊断、治疗和预后相关的具有潜在价值的肿瘤标志物,并有望成为肿瘤治疗的新靶点。就miR-128与恶性肿瘤关系的研究进展进行综述。
关键词:miR-128;恶性肿瘤;靶基因
 
Research progress on the relationship between miR-128 and malignant tumors
LI Mo-Lin1, WO Lu-Lu2, FU Hong-Yong1, FANG Long1, LI Chuan-Gang3, SHU Xiao-Hong4*
(1 Department of Pathophysiology, Dalian Medical University, Dalian 116044, China; 2 Department of Medicine, Dalian Medical University, Dalian 116044, China; 3 Division of Urology, Department of Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China; 4 College of Pharmacy, Dalian Medical University, Dalian 116044, China)
Abstract: MicroRNAs (miRNAs) are a class of small endogenous non-coding single chain RNAs containing 19~25 nucleotides, which regulate the expression of target genes through post-translational repression or mRNA degradation, thus further modulating its related signal transduction networks. MicroRNA-128 (miR-128) is a kind of brain-enriched miRNA, and plays important roles in the development of the nervous system and the maintenance of its normal physiological functions. It was reported that the aberrant expression of miR-128 is closely associated with glioma, Alzheimer’s disease, etc. Recent studies demonstrated that miR-128 is involved in proliferation, differentiation, apoptosis, invasion and metastasis of various tumor cells. miR-128 may serve as potential biomarkers for cancer diagnosis, treatment and prognosis, and is expected to become a new target for tumor therapy. In this review, we will focus on the relationship between miR-128 and malignant tumors.
Key words:  miR-128; malignant tumors; target genes
 
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