中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2013, 25(4): 396-401
维甲酸诱导基因I的新功能
崔会会,邱春红,鲁秀敏*
(重庆理工大学药学与生物工程学院,重庆 400054)
摘 要:维甲酸诱导基因I (retinoic acid inducible gene-I, RIG-I) 最广为人知的生物学功能是抗病毒作用,其抗病毒作用机理及信号通路受到广泛关注。最近研究表明,RIG-I 不仅具有抗病毒功能,还参与炎症反应、细胞增殖分化、吞噬或细胞凋亡、免疫调节等诸多生物学事件。对RIG-I 在抗病毒固有免疫及其他领域功能的最新研究发现作一综述。
关键词:维甲酸诱导基因I ;抗病毒;炎症;细胞增殖
 
Noncanonical function of retinoic acid inducible gene-I
CUI Hui-Hui, QIU Chun-Hong, LU Xiu-Min*
(College of Pharmacy and Biological Engineering, Chongqing University of Technology, Chongqing 400054, China)
Abstract: The antiviral role of retinoic acid inducible gene-I (RIG-I) has been well recognized, and most studies focus on its activation mechanism and down-stream signaling pathway in antiviral response. Recently, accumulating evidence suggests that RIG-I not only functions in antiviral systems but also participates in a series of biological events, such as inflammation, cell proliferation, differentiation, apoptosis and even immunoregulation. Here we review recent advances in antiviral study of RIG-I as well as its functions in other fields.
Key words: retinoic acid inducible gene-I (RIG-I); antiviral signaling; inflammation; cell proliferation
 
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