中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2013, 25(3): 311-314
硒蛋白P与神经退行性变化
李 菲,安书成*
(陕西师范大学生命科学学院,西安 710062)
摘 要:硒蛋白P (selenoprotein P, SelP) 对于硒转运及维持硒水平稳定非常重要。硒蛋白P 主要分布于小脑、嗅球、海马区和额叶皮质,神经元和星形胶质细胞中均有其表达,对神经细胞具有保护作用,在维持正常的脑功能中发挥着重要作用。硒蛋白P 基因敲除导致小鼠神经损伤,甚至死亡。硒蛋白P 与阿尔茨海默症、帕金森综合征、癫痫等神经退行性疾病的发生有关。重点介绍硒蛋白P 在神经退行性变化方面的作用。
 
Selenoprotein P and neurodegeneration
LI Fei, AN Shu-Cheng*
(College of Life Sciences, Shaanxi Normal University, Xi’an 710062, China)
Abstract: Selenoprotein P plays an important role in the transportation and homeostasis of selenium (Se). It is mainly distributed in the cerebellum, olfactory bulb, hippocampus and frontal cortex. The expression of selenoprotein P is observed in both neurons and astrocytes. Selenopotein P can protect nerves and is also importantfor maintaining the normal function of brain. The genetic deletion of selenoprotein P in mice can result in neurological dysfunction and even death. Selenoprotein P is also involved in neurodegeneration diseases including Alzheimer{$39}s disease, Parkinson{$39}s disease, and seizures. This paper focuses on the role of selenoprotein P in neurodegenerative changes.
 
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