中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2013, 25(2): 218-230
维生素D与癌症:研究现状和展望
李 绵,陈培战,李晓光,王 慧*
(中国科学院上海生命科学研究院营养科学研究所,上海 200031)
摘 要:维生素D 作为一类脂溶性必需维生素参与体内多种生物学过程,具有预防和治疗佝偻病、老年性骨折等功能。维生素D 不仅影响钙、磷的吸收和贮存,近年来研究发现体内维生素D 状态与多种肿瘤的发生发展显著相关,维生素D 水平与肿瘤关系成为肿瘤研究领域热点。就维生素D 和多种肿瘤如乳腺癌、结直肠癌之间的相关性研究现状和进展进行综述,并针对维生素D 在肿瘤发生发展中的分子机制及其临床应用进行探讨和展望。
关键词:维生素D ;癌症;乳腺癌;结直肠癌
 
Vitamin D and cancer: present status and future prospects
LI Mian, CHEN Pei-Zhan, LI Xiao-Guang, WANG Hui*
(Institution for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China)
Abstract: Vitamin D is a fat-soluble essential vitamin that participates in a variety of biological processes, especially in preventing and treating of rickets and senile fracture. Besides of its effect on the absorption and storage of calcium and phosphorus, experimental data suggest a protective effect of vitamin D on cancer. The relationship between vitamin D and cancer has become a hot topic in cancer research. Here, we briefly review the relationship between vitamin D and a variety of cancers, such as breast cancer and colorectal cancer, and have a discussion on the molecular mechanisms and clinical applications of vitamin D in cancer.
Key words: vitamin D; cancer; breast cancer; colorectal cancer
 
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