中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2013, 25(1): 28-35
IL-17+γδT细胞与疾病关联性的研究进展
周晓薇1,胡朝英2,张冬青1*
(1 上海交通大学医学院,上海市免疫学研究所,上海 200025;2 上海市徐汇区中心医院,上海 200031)
摘 要:γδT细胞是一群异质细胞,人和小鼠不同组织部位的γδT细胞亚群表型多变、功能丰富。γδT细胞经过胸腺选择,形成IL-17+γδT细胞、IFN-γ+γδT细胞或IL-4+γδT细胞,它的分化受到很多因素的调控。γδT细胞是炎症介质IL-17的重要来源,IL-17+γδT细胞可以参与多种疾病的诱发和发展,如过敏、自身免疫性疾病,甚至恶性肿瘤。此外,它们也在宿主防御中发挥保护作用,防治传染病和诱导细胞毒性T淋巴细胞对癌症的反应。就IL-17+γδT细胞的发育、分化和调节机制以及在各种疾病中的作用进行综述。
关键词:γδT细胞;IL-17;分化;感染;自身免疫性疾病;肿瘤
 
Research progress of IL-17 producing- γδT cell in disease
ZHOU Xiao-Wei1, HU Chao-Ying2, ZHANG Dong-Qing1*
(1 Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; 2 Central Hospital of Xuhui District, Shanghai 200031, China)
Abstract: γδT cells are a group of cells of high heterology, which can be divided into several phenotypic and functional categories. Through an unique thymic selection, γδT cells differentiate into IL-17 +γδT cells, IFN-γ+ γδT cells or IL-4+γδT cells, which is influenced by many factors. γδT is a source of IL-17, which is an important mediator of inflammation. IL-17+γδT cells participate in a variety of diseases, such as allergies, autoimmune disease and malignant tumor. In addition, they also play a protective role in host defense, promoting the response of CTLs to cancer. This paper reviewed IL-17+γδT cell development, differentiation and regulation mechanism as well as its roles in various diseases.
Key words: γδT cell; IL-17; differentiation; infection; autoimmune disease; tumor
 
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