中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(8): 858-866
铜稳态对铁代谢平衡的影响
郭飞龙,姜瑞伟,陈惠君*
(南京大学医学院,江苏省医学分子技术重点实验室,南京 210093)

摘 要:铜是人体必需的微量元素,参与体内多种蛋白和酶的组成,机体内存在严格的铜稳态调控机制。作为血浆中最主要的多铜亚铁氧化酶—— 铜蓝蛋白,与另外两种同源亚铁氧化酶—— 膜铁转运辅助蛋白和zyklopen,共同参与体内铁的转运,维持铁代谢的平衡。将对调节铜和铁平衡的重要意义以及铜和铁在机体代谢过程中的相互作用、发展动态进行讨论。
关键词:铜;多铜亚铁氧化酶;铁代谢平衡
中图分类号:O614.211 ;Q584 文献标志码:A


收稿日期:2012-06-29
基金项目:国家自然科学基金项目(81072292)
*通信作者:E-mail: hjchen@nju.edu.cn;Tel: 025-
83594785
 
The role of copper in iron metabolism and homeostasis
GUO Fei-Long, JIANG Rui-Wei, CHEN Hui-Jun*
(Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China)
Abstract: Copper and iron are essential micronutrients involved in a variety of biological processes indispensable to life. These metals are closely connected in part by the requirement of multicopper ferroxidases for maintenance of normal iron homeostasis. Multicopper ferroxidases are critical for the efficient export of iron from cells throughout the body. Currently, three major multicopper ferroxidases have been identified: ceruloplasmin (Cp), hephaestin (Hp), and zyklopen (Zp). This review highlights recent advances in copper-iron interactions with a focus on the tissues and cell types important for regulating whole-body copper and iron metabolism, and discusses extensive future research opportunities.
Key words: copper; multicopper ferroxidase; iron metabolism and homeostasis
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2954604 位访问者,欢迎!