中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(10): 1207-1210
保护胰岛β细胞的体外研究进展
周淑艳1,2,张 毅2,齐 晖2,李富荣1,2*
(1 暨南大学医学院,广州 510632;2 暨南大学第二临床医学院(深圳市人民医院) 临床医学研究中心,深圳 518020)

摘 要:糖尿病是一种由胰岛素分泌缺陷和(或)胰岛素作用缺陷引起的高血糖症性代谢疾病。自Edmonton临床试验取得成功后,胰岛移植成为一种新型治愈糖尿病的方法。但胰岛β细胞在体外分离过程中极易发生凋亡或死亡,且长期的体外培养或冷冻储存也容易令其胰岛素分泌功能逐渐丧失。因此,有效维持或改善β细胞的成活率及功能对胰岛移植的成功至关重要。对胰岛β细胞的体外保护方法进行阐述,并对其研究前景进行展望。


    

关键词:胰岛β细胞;胰岛移植;凋亡;体外保护; 糖尿病


    

中图分类号:Q28; Q813; R587.1   文献标志码:A

 
Research progress on protection of pancreatic β cells in vitro
ZHOU Shu-Yan1,2, ZHANG Yi1,2, QI Hui2, LI Fu-Rong1,2*
(1 Collage of Medicine, Jinan University, Guangzhou 510632, China; 2 Clinical Medical Research Center, Shenzhen People’s Hospital, 2nd Affilliated Hospital of Jinan University, Shenzhen 518020, China)

Abstract: Diabetes mellitus is a metabolic disease with the symptom of hyperglycemia caused by insulin secretion deficiency and (or) insulin action defects. Since the Edmonton clinical trials, islet transplantation has been considered as a new cure for diabetes. However, islet β cells are vulnerable to apoptosis or death during the isolation process. Furthermore, long time culture or cryopreservation in vitro could gradually deprive the functional activity of β cells. Therefore, maintaining or improving the survival and function of β cells is critical to the success of islet transplantation. In this review, protective methods of islet β cells in vitro had been described, and the research prospects outlined as supplement.


    

Key words: islet β cell; islet transplantation; apoptosis; protection in vitro; diabetes mellitus


    

收稿日期:2012-05-09; 修回日期:2012-07-10


    

基金项目:国家“973”前期专项资助项目(2007CB-516811);广东省自然科学基金项目(6027540)


    

*通信作者:E-mail: frli62@yahoo.com

 
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