中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(10): 1075-1081
DC-SIGN固有免疫调节及其表达调控机制研究进展
任建敏,张彦洁,王俊青,吴 菁,刘昕訸,杨 芬,许春娣,周 同*
(上海交通大学医学院附属瑞金医院,上海 200025)

 摘 要:DC-SIGN (DC-specific ICAM-3-grabbing non integrin, CD209)系C型凝集素家族主要成员,具有模式识别受体和介导细胞黏附功能。DC-SIGN可通过分子中凝集素糖识别域,识别多种病原体的外源性和机体内源性抗原以及细胞表面黏附分子(ICAM-2, 3)中甘露糖或岩藻糖的糖基团,并对话协调Toll 样受体等,介导树突状细胞(DC)等参与病原体或肿瘤细胞的免疫逃逸;也可调节DC黏附迁移并在炎症启动中激活初始T细胞免疫应答。因而,作为天然免疫分子介导基础,DC-SIGN在DC参与的感染性和炎症性疾病等的正负免疫调节中发挥了关键作用。目前有关DC-SIGN免疫调节效应涉及的信号转导以及分子表达调控机制尚未完全阐明,就相关进展作一综述。关键词:DC-SIGN;免疫调节;信号转导;表达机制


    

中图分类号:R392.12    文献标志码:A


    

 

 
Research progress on DC-SIGN medicated innate immunoregulation and regulatory mechanism of its expression
REN Jian-Min, ZHANG Yan-Jie,WANG Jun-Qing,WU Jing, LIU Xin-He, YANG Fen, XU Chun-Di, ZHOU Tong*
(Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China)

Abstract: DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) belongs to the major members of C-type lectin family, which is a PRR (pattern recognition receptor) and can mediate cell adhesion. DC-SIGN can specifically recognize glycoconjugates containing mannose or fucose in various exogenous antigen of pathogens, endogenous self-antigen and intercellular adhesion molecule 2,3 (ICAM-2, 3) by its lectin carbohydrate recognition domain. Moreover, it is also involved in immune escape of tumor cell or pathogens mediated by dendritic cells (DCs) through cross-talking with Toll like receptors. In the initial response of inflammation, DC-SIGN modulates the adhesion and migration of DCs to activate naive T-cell. Therefore, as an innate immune molecule, DC-SIGN plays an crucial role in infectious and inflammatory diseases through its positive and negative immunoregulatory effects on DCs. However, the immunoregulation mechanisms of DC-SIGN including signal transduction and expression regulation have not been fully elucidated. We have reviewed some progress in this field here.


    

Key words: DC-SIGN; immunoregulation; signal transduction; expression mechanism

 
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