中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(7): 660-665
miR-34家族在慢性淋巴细胞白血病中的作用
曹 烨1,孙志卫2,梁 拓1,刘 静2*
(1 中南大学生物科学与技术学院,长沙 410013;2 中南大学生物科学与技术学院分子生物学研究中心,长沙 410078)
摘 要:近年来的研究表明microRNAs 表达异常直接或间接导致了多种亚型慢性淋巴细胞白血病(chronic lymphocytic leukemia, CLL) 的发生。miR-34 家族( 包括miR-34a、miR-34b 与miR-34c) 是一个与细胞增殖、分化和癌变高度相关的microRNA 家族。近年来,人们发现miR-34 家族在p53 调控网络和CLL 发生中起着重要作用,并具有显著的临床应用价值。将对miR-34 家族在慢性淋巴细胞白血病发生中的作用和机制做一综述。
关键词:miR-34 家族; 慢性淋巴细胞白血病;p53 ;化学治疗抗性
 
The effect of miR-34 family on chronic lymphocytic leukemia
CAO Ye1, SUN Zhi-Wei2, LIANG Tuo1, LIU Jing2*
(1 School of Biological Science and Technology, Central South University, Changsha 410013, China; 2 Molecular Biology Research Center, School of Biological Science and Technology, Central South University, Changsha 410078, China)
Abstract: Recent research demonstrates that the expression abnormity of microRNAs, directly or indirectly, results in the occurrence of chronic lymphocytic leukemia (CLL) of various subtypes. MiR-34 family, including miR-34a, miR-34b and miR-34c, is a microRNA family closely relating to cell proliferation, differentiation and cancerization. Recently, researchers found that miR-34 family plays an important role in the regulatory network of p53 and CLL pathology. Meanwhile, its clinical value also reveals. In this review, the role of miR-34 family in the pathological
process of CLL is expounded.
Key words: miR-34 family; chronic lymphocytic leukemia; p53; chemotherapy resistance
 
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