中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(6): 583-587
胰腺星状细胞活化相关的信号转导通路
陈碧君,孙子林,李凤飞,杨家悦,李 玲*
(东南大学附属中大医院内分泌科,东南大学糖尿病研究所,南京 210009)
摘 要:胰腺纤维化是慢性胰腺炎(chronic pancreatitis, CP)和胰腺癌主要的病理学特征,活化的胰腺星状细胞(pancreatic stellate cells, PSCs)是公认的致胰腺纤维化的主要效应细胞。PSCs 的活化涉及到几个重要的信号转导通路:有丝分裂原活化蛋白激酶(mitogen-activated protein kinases, MAPK)、 磷酯酰肌醇3激酶 (phosphatidylinositol 3-kinase, PI3K)=、 Smad信号转导蛋白、过氧化物酶体增生物激活受体-γ (PPAR-γ)、 Rho-ROCK 等细胞内信号途径。探讨这些信号通路在胰腺纤维化中所起的作用对慢性胰腺炎、胰腺癌及糖尿病的治疗有重要意义。现就与 PSCs 激活有关的信号通路的研究结合最新进展作一综述。
关键词:胰腺星状细胞;信号转导;胰腺纤维化
 
The signaling pathways in pancreatic stellate cells
CHEN Bi-Jun, SUN Zi-Lin, LI Feng-Fei, YANG Jia-Yue, LI Ling*
(Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Southeast University, Nanjing 210009, China )
Abstract: Pancreatic fibrosis is one of the dominant pathological characters of chronic pancreatitis and pancreatic cancer. Activated pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis. The activation of PSCs is regulated by several signaling transduction pathways: mitogen-activated protein kinases (MAPK), phosphatidy-linositol 3-kinase (PI3K), Smad signaling transduction protein, peroxisome proliferator-activated receptor (PPAR), Rho-ROCK. Identification of signaling molecules that play a crucial role in PSCs activation is important for the development of anti-fibrotic therapies. This review aims at summarizing the signaling transduction pathways that associated with the activation of PSCs and highlighting the recent advancements.
Key words: pancreatic stellate cells; signaling transduction; pancreatic fibrosis
 
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