中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(6): 568-577
NOX家族蛋白的研究进展
韩晓燕1,高丽萍1, 刘 箐2*
(1 兰州大学基础医学院生物化学与分子生物学研究所,兰州 730000;2 上海理工大学医疗器械与食品学院,上海 200093)
摘 要:NADPH氧化酶催化亚基gp91phox(NOX2)及其同源物NOX1、NOX3、NOX4、NOX5、DUOX1和DUOX2统称为NOX家族,它们作为NADPH酶的核心亚基,是该酶发挥作用的关键。NOX家族几乎存在于所有的细胞,吞噬细胞中NADPH氧化酶生成的ROS主要起细胞防御功能,与此不同的是非吞噬细胞中NADPH氧化酶产生的ROS作为信号分子,参与机体内信号转导途径,调节细胞分化、增殖、衰老和凋亡等活动;当NOX家族蛋白异常表达,ROS水平急剧增加时,则能诱导机体内多种疾病的发生。
关键词:NOX家族;ROS;表达;结构;活化;功能
 
The development of NOX family proteins
HAN Xiao-Yan1, GAO Li-Ping1, LIU Qing2*
(1 Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China; 2 School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093,China)
Abstract: The catalytic subunit gp91phox (NOX2) of NADPH oxidase and its homologues NOX1, NOX3, NOX4, NOX5, DUOX1 and DUOX2 are collectively referred to as the NOX family. NOX family proteins play a key role in NADPH oxidase function as the core subunits of the NADPH enzyme. In recent years, a large number of studies show that NOX family proteins exist in almost all cells. NADPH oxidase-generated ROS plays a cellular defense function in the phagocytic cells, the difference is that the ROS is generated by NOX family in non-phagocytic cells as a signaling molecule, involving in signal transduction and regulating cell differentiation, proliferation, senescence and apoptosis. When the abnormal expression of NOX family proteins lead to a sharp increase in ROS levels, the oxidative stress can induce many diseases.
Key words: NOX family; ROS; structure; expression; activation; function
 
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