中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(6): 511-517
亮氨酰-tRNA合成酶通过细胞内的亮氨酸调节雷帕霉素受体复合物(TORC1)活性的新功能
谭 敏,王恩多*
(中国科学院上海生命科学研究院生物化学与细胞生物学研究所,分子生物学国家重点实验室,RNA研究中心,上海 200031)
摘 要:TORC1 (target of rapamycin complex 1)可整合营养、能量、生长因子及氨基酸等多种细胞外信号,调控基因转录、蛋白质翻译、核糖体合成等生物过程,在细胞生长和凋亡中发挥极为重要的作用。亮氨酰-tRNA合成酶(LeuRS)的经典功能是催化合成亮氨酰-tRNA直接参与遗传信息的解码合成蛋白质。最新研究结果表明人细胞质LeuRS除了经典功能外,还参与调控TORC1途径。综述了LeuRS的非经典功能,它是如何通过感受细胞内的亮氨酸浓度来调节TORC1活性的。这些结果表明了古老的氨基酰-tRNA合成酶家族在进化的过程中被赋予了新的功能。
关键词:亮氨酰-tRNA 合成酶;非经典功能;雷帕霉素受体复合物1(TORC1);亮氨酸
 
Noncanonical function of leucyl-tRNA synthetase — regulating TORC1-signaling pathway through sensing intracellular leucine
TAN Min, WANG En-Duo*
(Center for RNA Research, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)
Abstract: TORC1 regulates translation and cell growth in response to a variety of signals, including hormones, growth factors, energy levels, and amino acids such as leucine. The dysregulation of TORC1 pathway is associated with several hamartoma syndromes and cancers. Leucyl-tRNA synthetase (LeuRS) catalyzes the formation of Leu-tRNA for decoding the genetic information. Recent works reveal that the pathway for leucine signaling to TORC1 is mediated by LeuRS, which functions as a sensor for intracellular leucine. These results show that an old family of aminoacyl-tRNA synthetases is conferred new function during the evolution.
Key words: leucyl-tRNA synthetases; noncanonical function; TORC1; leucine
 
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