中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(6): 502-510
谷氨酰-脯氨酰-tRNA合成酶的非经典功能 ——炎症相关基因特异性的翻译沉默
姚 鹏1,王恩多2*
(1 美国克里夫兰医学中心 Lerner 研究所,细胞生物学系,克里夫兰 44195;2 中国科学院上海生命科学研究院生物化学与细胞生物学研究所,分子生物学国家重点实验室,RNA研究中心,上海 200031)
摘 要:氨基酰-tRNA 合成酶 (aaRS) 催化氨基酰化反应,为生物体内的蛋白质合成提供原料。哺乳动物细胞质中一种双功能aaRS谷氨酰-脯氨酰-tRNA合成酶 (EPRS) 通常负责将谷氨酸和脯氨酸分别接载到对应的tRNA的3{$39}末端参与蛋白质翻译;此外,它还具有与氨基酰化经典功能无关的单核/巨噬细胞特异性炎症相关基因翻译沉默的非经典功能。在过去的十五年间,对于 EPRS 参与炎症反应相关基因表达调控的功能研究取得了一系列重要进展,揭示了看家基因 EPRS 与人类疾病发生和发展的潜在联系。
关键词:谷氨酰-脯氨酰-tRNA 合成酶;非经典功能;翻译沉默;炎症
 
Noncanonical function of glutamyl-prolyl-tRNA synthetase —inflammatory gene-specific translational silencing
YAO Peng1, WANG En-Duo2*
(1 Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland 44195, USA; 2 Center for RNA Research, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)
Abstract: Aminoacyl-tRNA synthetases (aaRSs) catalyze aminoacylation of their cognate tRNAs for protein biosynthesis. Mammalian cytosolic dual-functional enzyme glutamyl-prolyl-tRNA synthetase (EPRS) is generally responsible for charging the amino acids Glu and Pro to the 3{$39}-end of their cognate tRNAs for initiation of protein translation; the enzyme EPRS also possesses noncanonical function as monocyte/macrophage-specific translational silencing of inflammatory gene expression beyond the canonical aminoacylation function. During the past 15 years, important progresses have been made on functional research about EPRS-directed regulation of inflammatory gene expression, revealing potential relation between the “house-keeping” enzyme EPRS and the development of human diseases.
Key words: glutamyl-prolyl-tRNA synthetase; noncanonical function; translational silencing; inflammation
 
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