中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(5): 439-443
LEF-1的调控及其与肿瘤的关系研究进展
崔婷婷,谢 楠,张小莉,吴琴丰,聂红娟,杨敏敏,陈亦雯,侯颖春*
(陕西师范大学生命科学学院,陕西 710062)
摘 要:淋巴细胞增强因子(lymphoid enhancer factor, LEF-1) 是Wnt 信号通路中的一个重要调控因子。其异常表达对肿瘤细胞增殖和凋亡调控起关键作用。LEF-1 作为Wnt 信号通路核内的转录因子,还与T 细胞受体α (TCRα) 的增强子相互作用形成特定的构象,从而与其他因子结合共同调节基因的表达。同时,LEF-1 为一多启动子基因,编码产生致瘤的全长形式的LEF-1 和对Wnt 信号通路起负向调控作用的截短形式的LEF-1。诸多研究结果表明肿瘤的发生发展与LEF/TCF 各亚型的比例有关。就Wnt/LEF-1 信号通路的调控以及与肿瘤的关系做一综述。
关键词:LEF-1 ;Wnt 信号通路;调控;肿瘤
 
Advances of the study on the regulation of Wnt/LEF-1 signal pathway and the relation with tumor
CUI Ting-Ting, XIE Nan, ZHANG Xiao-Li,WU Qin-Feng, NIE Hong-Juan, YANG Min-Min, CHEN Yi-Wen, HOU Ying-Chun*
(College of Life Sciences, Shaanxi Normal University, Xi’an 710062, China)
Abstract: LEF-1 is an important regulator in Wnt signaling pathway, its abnormal expression plays a key role in the cell proliferation and apoptosis, especially for the tumor cells. As a key regulator of Wnt signaling pathway, the specific conformation assembled by LEF-1 and T cell receptor α (TCRα) enhancer regulates gene expression with other factors together. Additionally, LEF-1 is a multi-promoter driving gene and encodes a full-length form of the LEF-1 involving in oncogenesis and a truncated form of the LEF-1 regulating Wnt signaling pathway negatively. Reported data shows that the oncogenesis and tumor development are closely associated with the expression level change of LEF / TCF subtypes. We review the recent advances about LEF-1 as a regulator in Wnt pathway and its relationship with oncogenesis and progression of tumors in this paper.
Key words: LEF-1; Wnt signal pathway; regulation; tumor
 
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