中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2007, 19(2): 208-
生长激素/胰岛素样生长因子1与阿尔茨海默病
张 婷,孙曼霁*
军事医学科学院毒物药物研究所,北京 100850
摘 要:生长激素/胰岛素样生长因子-1(GH/IGF-1)轴的合成、分泌、调节及生物学活性与阿尔茨海默病(AD)有密切关系。生长激素(GH)的合成和分泌受生长激素释放激素(GHRH)正向调节。GH/IGF-1轴活性下降导致一系列生理功能变化。GH/IGF-1 缺乏可引起衰老及神经退行性变(AD)而导致认知功能的下降,相应激素的补给可以抑制或逆转这种认知障碍。越来越多的证据表明:GH/IGF-1参与AD型痴呆病理过程,对AD有很好的治疗应用前景。本文就生长激素/胰岛素样生长因子1在AD发病中的机理和药理学研究做一综述。
关键词:生长激素;胰岛素样生长因子1;阿尔茨海默病
 
Growth hormone/insulin-like growth factor 1 and Alzheimer’s disease
ZHANG Ting, SUN Manji*
Institute of Pharmacology and Toxicology , Beijing 100850, China
Abstract: The synthesis, secretion, regulation and biological activity of the growth hormone (GH) / insulin-like growth factor- 1 (IGF-1)  play important parts in the development of Alzheimer{$39}s disease (AD).  The synthesis and secretion are regulated by the stimulants, the GH-releasing hormone (GHRH).   Decrement of the activity of the somatotrophic axis causes a series of changes of physiological functions.  The deficiency of GH/IGF-1 results in aging and decline of cognition. Supplementation of the related hormones will protect or reverse the cognitive deficits. The evidence available strongly indicates that GH / IGF-1 therapy in Alzheimer{$39}s dementia may be addressing pathogenic processes. The role of GH/IGF-1 in the development of Alzheimer{$39}s disease and pharmacological research are reviewed
Key words: growth hormone; insulin-like growth factor 1; Alzheimer{$39}s disease
 
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