中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
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《生命科学》 2012, 24(3): 211-216
家蚕细小病毒样病毒的研究进展
李光田,郭旭丽,朱守林,马 瑛,胡朝阳,李国辉,陈克平,姚 勤*
(江苏大学生命科学研究院,镇江212013)


摘 要:家蚕细小病毒样病毒(Bombyx mori parvo-like virus, BmPLV) 是一种二分病毒,该病毒在家蚕中肠柱状细胞核内复制和包装,感染的细胞核呈现过分膨胀、细胞核孚尔根浓染等细胞病理学特征。病毒粒子直径20~24 nm,无囊膜呈球型。基因组为单链线性双分子DNA (VD1、VD2),分别独立包装在各自的衣壳中。病毒编码四个非结构蛋白NS1、NS2、NS3 和pol (DNA 聚合酶),一个主要结构蛋白VP 及次要结构蛋白P133。其基因组末端反向重复序列可形成与BmPLV 复制有关的“锅柄形”结构,以及含自身编码的DNA 聚合酶的序列,推测该病毒与腺病毒复制方式相类似,依靠共价蛋白为起始物完成复制。
关键词:家蚕细小病毒样病毒;中肠;DNA 聚合酶
中图分类号:S884.5; Q523 文献标志码:A
 

 
Recent research on Bombyx mori parvo-like virus
LI Guang-Tian, GUO Xu-Li, ZHU Shou-Lin, HU Zhao-Yang, LI Guo-Hui, CHEN Ke-Ping,YAO Qin*
(Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China)
Abstract: Bombyx mori parvo-like virus (BmPLV) is an animal bipartite virus, replicates and packs in the nucleus of columnar cells of midgut epithelium, and causes the cell nuclei of infected cells over-expanded and stainned. The virus particles are small icosahedra, non-enveloped particles 20-24 nm in diameter. The genome contains two single-stranded DNA (VD1、VD2), and each strand is packaged in a separate virus particle. It encodes 4 nonstructural proteins NS1, NS2, NS3 and pol (DNA polymerase), one major structural protein VP and a sub-structural protein P133. It can be formed a "panhandle-shaped" structure with both ends of inverted repeat sequences, and its own encoding DNA polymerase, which suggests the replication will be completed by depending on covalent protein of the virus.
Key words: Bombyx mori parvo-like virus (BmPLV); midgut; DNA polymerase
 
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