中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(2): 185-190
线粒体相关的疾病治疗及干预策略
郑斌娇1,梁 敏1,薛 凌1,郑 静1,张 婷1,龚莎莎1,方 芳1,吕建新1,管敏鑫1,2*
(1 温州医学院,Attardi线粒体生物医学研究院和浙江省医学遗传学重点实验室,温州 325035;2 浙江大学生命科学学院,杭州 310058)
摘 要:线粒体疾病是一种累及不同的组织和器官的复杂异质性疾病,由核基因或线粒体基因的遗传缺陷导致,同时也受环境因素的影响。近十年来,有关线粒体疾病的诊断及发生机制的研究进展迅速,而疾病的治疗方法却研究较少。着重介绍线粒体疾病的相关治疗方法和干预策略。
关键词:线粒体疾病;基因治疗;氧化磷酸化缺陷;异质性
 
Therapeutic and tampering approaches for mitochondrial associated diseases
ZHENG Bin-Jiao1, LIANG Min1, XUE Ling1, ZHENG Jing1, ZHANG Ting1, GONG Sha-Sha1, FANG Fang1, Lv Jian-Xin1, GUAN Min-Xin1,2*
(1 Attardi Institute of Mitochondrial Biomedicine and Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou 325035, China; 2 College of Life Sciences, Zhejiang University, Hangzhou 310058, China)
Abstract: As heterogeneous disorders, mitochondrial diseases can affect various tissues and organs. They can be caused by genetic defects (nuclear and mitochondrial DNA) or environmental factors. Last decades, substantial progress has been made among the diagnosis and pathogenesis of mitochondrial diseases. However, there have been not many reports about development of therapies approaches for these disorders. In this review article, we will discuss emerging therapeutic and intervention strategies of mitochondrial diseases.
Key words: mitochondrial diseases; gene therapy; oxidative phosphorylation defects; heteroplasmy
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2954429 位访问者,欢迎!