中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(2): 174-180
表位疫苗的设计及应用研究进展
赵 德1,冯 磊1,张 强2,郭建宏2,高凤山1,2*
(1 大连大学生命科学与技术学院,分子免疫学实验室,大连 116622;2 中国农业科学院兰州兽医研究所,家畜疫病病原微生物国家重点实验室,兰州 730046)
摘 要:表位疫苗相对传统疫苗拥有较多优势,其最大的优点就是可以克服传统疫苗造成的毒力恢复或散毒的可能。另外表位疫苗本身无毒、稳定,符合未来疫苗发展的方向。表位疫苗的设计需要从表位的筛选、优化及表位的组合等多方面展开。现对表位疫苗的设计策略及应用作一介绍。
关键词:表位疫苗;筛选; 优化;抗原
 
Design and application of epitope-vaccines
Zhao De1, Feng Lei1, Zhang Qiang2, Guo Jian-Hong2, Gao Feng-Shan1,2*
(1 Laboratory of Molecular Immunology, College of Life Science and Technology, Dalian University, Dalian 116622, China; 2 Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China)
Abstract: Comparing to traditional vaccines, epitope-vaccine displays many advantages. The most outstanding advantage for epitope-vaccine is that it can avoid the disadvantages of virus-excretion and virulence recovery. In addition, the epitope-vaccine is atoxic and stable. Therefore, the epitope-vaccine meets to the developing direction of future vaccine. Design of epitope-vaccine needs to carry out from epitope-screening, optimization and assemblage of epitopes, etc. Presently, we will give an introduction to designing strategy and application of epitopevaccine.
Key words: epitope-vaccine; screening; optimization; antigen
 
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