中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(1): 63-68
COX-2与糖尿病并发症关系研究进展
张一弛,牟艳玲,解砚英*
(山东省医学科学院药物研究所,山东省罕少见病重点实验室,济南 250062)
摘 要:糖尿病是一种慢性、低度炎症性疾病。多种因素刺激下,环氧化酶COX-2在胰岛及多种组织中高水平表达。它通过与炎症因子和炎症介质,如一氧化氮、核因子-κB、前列腺素E等相互作用,对相应组织产生作用,从而促进了糖尿病并发症的发生和发展。对COX-2的研究可进一步揭示糖尿病并发症发生的分子机制,为预防和治疗糖尿病并发症提供新的思路。
关键词:COX-2;糖尿病;糖尿病并发症;炎症反应
 
Research progress in relations between cyclooxygenase 2 and diabetes mellitus complications
ZHANG Yi-Chi, MOU Yan-Ling, XIE Yan-Ying*
(Key Laboratory for Rare Disease of Shandong Province, Depantment of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China)
Abstract: Recently, diabetes mellitus is viewed as a chronic and low level inflammation disease. Stimulated by several factors, cyclooxygenase-2 (COX-2) is over expressed in pancreatic cells and other tissues. Interacting with some inflammatory factors and inflammatory mediators, such as nitric oxide, nuclear factor-κB, and prostaglandin E, it can produce the effects on corresponding tissues. COX-2 plays a crucial role in the pathogenesis and progress of diabetic complications. Further researches of COX-2 will be helpful in revealing the molecular mechanisms of diabetes complications, and will provide us a new way to prevent and treat diabetes mellitus.
Key words: COX-2; diabetes mellitus; diabetic complications; inflammation
 
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