中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2012, 24(1): 54-57
促炎症消退新介质:消退素与保护素
袁红梅1,万敬员1,张 力2*
(1 重庆医科大学药理学教研室,重庆 400016;2 重庆医科大学病理生理学教研室,重庆 400016)
摘 要:炎症启动(initiation)、发展之后的消退(resolution)是受到体内促消退介质(pro-resolving mediator)调控的主动过程。继发现由花生四烯酸衍生的脂氧素(lipoxin)后,新近又从炎症消退阶段的炎性渗出物中分离出由ω-3多不饱和脂肪酸转化而来的消退素(resolvin)与保护素(protectin),它们也具有强效的抗炎促消退效应,成为促炎症消退介质的新成员。
关键词:消退素;保护素;炎症;炎症消退;不饱和脂肪酸
 
Novel pro-resolving mediators: resolvin and protectin
YUAN Hong-Mei1, WAN Jing-Yuan1, ZHANG Li2*
(1 Department of Pharmacology, Chongqing Medical University, Chongqing 400016, China; 2 Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China)
Abstract: The resolution phase of inflammation, subsequent to its initiation and development phase, is an active process regulated by endogenous pro-resolving mediators. Following the discovery of lipoxin derived from arachidonic acid, the ω-3 polyunsaturated fatty acids (PUFAs)-derived resolvin and protectin were recently identified from the inflammatory exudates during the spontaneously resolution phase of inflammation. They are new members of pro-resolving mediator family with potent anti-inflammatory and pro-resolving effects.
Key words: resolvin; protectin; inflammation; inflammation resolution; polyunsaturated fatty acids
 
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