中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
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《生命科学》 2012, 24(1): 13-18
肌动蛋白解聚因子/cofilin功能的研究进展
徐 阳,原丽平,陈金铃,黄晓红*
(福建师范大学生命科学学院,福建省发育与神经生物学重点实验室,福州 350108)
摘 要:肌动蛋白解聚因子(actin depolymerizing factor, ADF)/cofilin家族是一类肌动蛋白结合蛋白,它们通过切断肌动蛋白纤丝并结合到肌动蛋白单体上,在重塑肌动蛋白骨架中发挥重要作用。就ADF/cofilin家族的结构特点、调控肌动蛋白动力学的机制及其功能的最新研究进展做一简要综述,并指出了目前在ADF/cofilin功能研究方面的不足和尚需解决的问题。
关键词: ADF/cofilin家族蛋白;调控机制;功能
 
Research progress on functions of ADF/cofilin
XU Yang, YUAN Li-Ping, CHEN Jin-Ling, HUANG Xiao-Hong*
(Fujian Key Laboratory of Developmental and Neurobiology, College of Life Science,Fujian Normal University, Fuzhou 350108, China)
Abstract: The actin depolymerizing factor/cofilins are a family of actin-binding proteins, which remodel the actin
cytoskeleton through severing actin filaments and binding to actin monomers.The structural features of ADF/cofilin
family and regulatory mechanism of actin dynamics were reviewed in this paper, the new progress on functions of
ADF/cofilin were also clarified in detail. It was proposed that there existed deficiency and some unsolved problems
in the research on the functions of ADF/cofilin.
Key words: ADF/cofilin family; regulatory mechanism; function
 
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