中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(10): 1027-1033
COX-2/Nrf2/ARE信号通路与体内外的抗炎、抗氧化作用机理
刘 薇1, 王红霞1,王立魁2,苏丽丽3,罗 成1*
(1 天津科技大学食品工程与生物技术学院,天津 300457;2 首都医科大学附属北京友谊医院,北京 100050;3 新泽西州立大学,癌症预防研究中心,罗格斯,新泽西 08854,美国)
摘 要:近年新研究发现COX-2 可使用比COX-1 更广泛的底物。比如,除了标准的花生四烯酸外,COX-2 也能将二十二碳六烯酸(DHA) 和二十碳五烯酸 (EPA) 等转换成前列腺素衍生物。这些前列腺素衍生物可进一步转化成促进消炎、 抗氧化的亲电羰基衍生物(EFOX) 分子, 并且可以从Keap1 解离转录因子Nrf2,继而可以激活多种与抗氧化相关的含ARE 应答元件的基因, 如血红素氧化酶-1、谷胱甘肽还原酶等。COX-2 的这些新功能有可能帮助更好地理解Nrf2/ARE 信号通路及其抗炎、抗氧化、诱导肿瘤细胞凋亡等机理。对外源性抗氧化剂触发体内的抗氧化基因及抗炎信号的可能性,以及与饮食相关的抗衰老机理进行
探讨。
关键词:COX-2 ;Nrf2/ARE ;抗炎;抗氧化;多糖
中图分类号:Q559 文献标志码:A




 
COX-2 and Nrf2/ARE signaling pathways in anti-inflammation and antioxidation in vivo and in vitro
LIU Wei1, WANG Hong-Xia1, WANG Li-Kui2, SAW Constance Lay-Lay3, LUO Cheng1*
(1 School of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457,China; 2 Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; 3 Center for Cancer Prevention
    Research, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, NJ 08854, USA)
Abstract: Recent studies have revealed that multiple substrates of the cyclooxygenase (COX)-2 enzyme, such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in addition to the standard substrate, arachidonic
acid(AA), and COX-2 dependent electrophilic oxo-derivatives (EFOX) release Nrf2 by changing Keap1 conformation, subsequently Nrf2 activates the antioxidative response elements (ARE), such as heme oxygenase-1, glutathione reductase, etc. These findings suggest the involvement of COX-2 and Nrf2/ARE in anti-inflammatory and anti-oxidative mechanisms. In this study, we discussed the correlations present between exogenous and endogenous factors in anti-oxidation and anti-inflammation, and propose a putative mechanism of anti-ageing involving commonly found dietary-herbal compounds.
Key words: COX-2; Nrf2/ARE; anti-inflammation; anti-oxidation; polysaccharides
 
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