中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(8): 773-778
PLMT家族成员SET7/9的非组蛋白甲基化作用
高丽丽,余卫平*
(东南大学医学院病理学与病理生理学系,南京 210009)
摘 要:SET7/9是蛋白赖氨酸甲基化转移酶(protein lysine methyltransferases, PLMTs或PKMTs)家族成员,具有SET结构域。现已发现SET7/9是一种赖氨酸单甲基化转移酶,除了能使组蛋白H3第四位赖氨酸(lysine 4 of histone 3, H3K4)单甲基化外,更重要的能使一些转录因子、肿瘤抑制因子、膜相关受体等非组蛋白单甲基化,其甲基化作用主要与蛋白稳定和转录活化有关。该效应受赖氨酸特异性去甲基酶1(lysine specifc demethylase, LSD1)的抑制。SET7/9与LSD1两者效应的平衡对维持体内活性蛋白质含量、调节基因表达具有重要意义。
关键词:SET7/9;赖氨酸甲基化转移酶;非组蛋白;甲基化作用
 
Methylation of non-histone proteins by SET7/9, a member of PLMT family
GAO Li-Li, YU Wei-Ping*
(Department of Pathology and Pathophysiology, College of Medicine, Southeast University, Nanjing 210009, China)
Abstract: SET7/9 is a member of protein lysine methyltransferase family. It contains a SET domain. Recent studies demonstrate that SET7/9 methylates both lysine 4 of histone 3 (H3-K4) and lysine(s) of non-histone proteins including transcription factors, tumor suppressor and membrane-associated receptors,so on. SET7/9 is exclusively a monomethyltransferase, and it is mainly related to protein stabilization and transcriptional activation. Additionally, mathylation by SET7/9 can be blocked by lysine specifc demethylase 1(LSD1). Thus, the equilibrium of effects between SET7/9 and LSD1 is important to maintain the content of some active proteins and to regulate the expression of some genes.
Key word: SET7/9; lysine methyltransferase; non-histone protein; methylation
 
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