中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(8): 736-741
HLA-G诱导DC细胞在免疫耐受机制中的研究进展
许惠惠,阮嫣赟,颜卫华,林爱芬*
(温州医学院附属浙江省台州医院中心实验室,临海 317000)
摘 要:树突状细胞(dendritic cells, DC)是体内最重要的专职抗原递呈细胞,具有刺激初始型T细胞增殖,启动机体免疫反应并决定免疫应答方向的功能。人白细胞抗原-G(human leukocyte antigen -G, HLA-G)属于非经典的HLA-I类分子,能够调控DC的细胞表型和细胞因子表达谱,诱导DC获得致免疫耐受功能。耐受型DC呈现未成熟或半成熟样,释放IL-10等抑制性细胞因子和表达免疫球蛋白样转录受体4(immunoglobulin-like transcript 4, ILT4)等HLA-G受体,继而诱导产生调节性T细胞(regulatory T cells, Treg)。对HLA-G诱导产生耐受型DC细胞及其免疫学功能作一综述。
关键词:HLA-G;树突状细胞;免疫耐受
 
Recent progress of HLA-G-modified DC cells in tolerogenic immune mechanism
XU Hui-Hui, RUAN Yan-Yun, YAN Wei-Hua, LIN Ai-Fen*
(Laboratory Center, Wenzhou Medical College Affiliated Taizhou Hospital of Zhejiang Province, Linhai 317000, China)
Abstract: Dendritic cells (DC) are the most important professional antigen presenting cells (APCs), which have the functions of stimulating the proliferation of naïve T cells, initiating immune response, and inducing immunity or immunologic tolerance. Human leukocyte antigen (HLA)-G, a non-classical HLA class I molecule, is involved in the generation of tolerogenic DCs, which express high levels of immunoglobulin-like transcript (ILT)-4, secrete high amounts of IL-10, and induce allospecific regulatory T cells (Treg) in vivo and in vitro. In the present review, we discuss current findings on the functional plasticity of tolerogenic DC induced by HLA-G.
Key words: HLA-G; dendritic cell; immune tolerance
 
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