中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(7): 643-647
N-乙酰氨基葡萄糖转移酶(OGT)研究进展
孙 红,马晓峰,任飞飞,张连文,王 鹏*
(南开大学药学院,天津300071)
:  O-GlcNAc是一种广泛存在于蛋白质丝/苏氨酸残基上的动态、可逆的蛋白翻译后修饰,它广泛分布在细胞浆和细胞核中,参与调节多种细胞途径。研究表明蛋白的O-GlcNAc糖基化与神经退行性疾病、糖尿病和癌症等疾病相关。在体内,O-GlcNAc动态修饰由N-乙酰氨基葡萄糖转移酶(OGT)和N-乙酰氨基葡萄糖苷酶(OGA)协同完成。近年来,OGT逐渐成为糖生物学领域的研究热点,在其结构、作用机制及晶体学方面取得了快速发展。

    
关键词:  O-GlcNAc糖基化;N-乙酰氨基葡萄糖转移酶(OGT);作用机制;晶体结构

    
中图分类号:Q55  文献标志码:A
 
A review on N-acetylglucosamine transferase (OGT)
SUN Hong, MA Xiao-Feng, REN Fei-Fei, ZHANG Lian-Wen, WANG Peng*
(College of Pharmacy, Nankai University, Tianjin 300071,China)
Abstract: N-acetylglucosamine (O-GlcNAc) modification on protein serines/threonines is a dynamic, inducible and abundant post-translational modification, which is found on numerous cytoplasm and nucleus proteins, regulating many cellular processes. It has been demonstrated that O-GlcNAc plays important roles in some human diseases, such as diabetes and neurodegenerative diseases. O-GlcNAcylation is regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) in vivo. The past decades has seen a mass of research on OGT, include studies on the protein structure and the mechanism linked to many important diseases. Recently, OGT is becoming the spotlight in glyco-biological research.
Key words:O-GlcNAc modification;N-acetylglucosamine transferase (OGT);mechanism of action;crystallography
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2952828 位访问者,欢迎!