中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(6): 605-611
N-糖基化位点鉴定方法和非经典N-糖基化序列
周 蕾,顾建新*
(复旦大学上海医学院,卫生部糖复合物重点实验室,上海 200032)
摘 要:蛋白质的N- 糖基化修饰是生物体调控蛋白质在组织和细胞中的定位、功能、活性、寿命和多样性的一种普遍的翻译后方式。N- 糖基化位点是理解糖链功能的重要前提之一。应用新的糖蛋白、糖肽富集技术和质谱技术,科学家们在不同组织中完成了对N- 糖基化位点的鉴定。此外,不同于经典三联子的N- 糖基化序列的发现使人们对N- 糖基化过程的认识向纵深发展。
关键词:N- 糖基化;糖基化位点;非经典序列
中图分类号:Q513.3 文献标志码:A
 
N-glycosylation sites analysis and nonconsensus N-glycosylated sequences
ZHOU Lei, GU Jian-Xin*
(Key Laboratory of Glycoconjugate Research, Ministry of Health; Shanghai Medical College, Fudan university, Shanghai 200032, China)
Abstract: N-glycosylation of proteins is the most common post-tranlational modification, strongly influencing many of their location, function, activity, life span and diversity. Our knowledge to N-glycosylation sites is one of the most important prerequisites for detailed functional understanding. Using new methods based on glycoproteins/glycopeptides enrichment and mass spectrum techniques, scientists have been able to identify glycosylated sites in different tissues. Besides, the discovery of novel sequence patterns for N-glycosylation will help to understand the process of N-glycosylation better in future.
Key words: N-glycosylation; glycosylation sites; nonconsensus sequences
 
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