中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(5): 503-510
白桦脂酸的研究进展
徐 军,王晋萍,钱辰旭,仇文卫*,杨 帆,汤 杰
(华东师范大学化学系药物化学研究所,上海 200062)
摘 要:白桦脂酸是一种五环三萜酸,存在于多种天然植物,特别是白桦树皮中,毒性低,安全指数高。近年来发现白桦脂酸具有抗肿瘤、抗HIV、抗炎、抗菌、抗疟疾等多种生物活性,特别是在抗黑色素瘤与抗HIV方面具有突出的表现,从而引起了人们极大的研究兴趣。对白桦脂酸的来源和生物活性进行了简要综述。
关键词:白桦脂酸;白桦脂酸制备;生物活性;肿瘤;抗HIV
 
Progress of study on betulinic acid
XU Jun, WANG Jin-Ping, QIAN Chen-Xu, QIU Wen-Wei*, YANG Fan, TANG Jie
(Institute of Medicinal Chemistry, Department of Chemistry, East China Normal University,Shanghai 200062, China)
Abstract: The betulinic acid (BA), a type of pentacyclic triterpene acid, which is found in the bark of several species of plants, principally the white birch. It has a variety of biological activities, such as anti-tumor, anti-HIV, anti-inflammatory, antimicrobial, and antimalarial activity, especially in anti-melanoma and anti-HIV show great promise. In this paper, the preparation and bioactivities of betulinic acid are reviewed.
Key words: betulinic acid; preparation of betulinic acid; biological activity; tumor; anti-HIV
 
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