中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(4): 390-393
猪的全基因组水平SNP研究现状
陈慧勇1,罗赛群1,吴珍芳2*
(1 中南大学生物科学与技术学院分子生物学研究中心,长沙 410078;2 华南农业大学动物科技系,广州 510640)
摘 要:SNP(single nucleotide polymorphism,单核苷酸多态)在猪基因组中的分布极其广泛,平均分布间隔为300~400 bp,相关数据库收录已达55万条。猪基因组测序已取得实质性进展,大规模搜索发现基因组及EST(expressed sequence tag)序列中的SNP已展开,应用于猪全基因组水平的SNP芯片已建立。在此基础上,基于猪SNP标记的遗传图谱绘制、QTL(quantitative trait loci)定位、遗传多样性检测及全基因组关联分析等也都相继出现。
关键词:猪;SNP;全基因组关联分析
 
Progresses of SNP in pig genome-wide studies
CHEN Hui-Yong1, LUO Sai-Qun1, WU Zhen-Fang2*
(1 Molecular Biology Research Center, College of Biological Science and Technology, Central South University, Changsha 410078, China; 2 Department of Animal Science, South China Agricultural University, Guangzhou 510640, China)
Abstract: Single nucleotide polymorphisms (SNPs) are abundant and widespread throughout the pig genome, occurring typically on average every 300-400 bps. About 557 k SNPs have been deposited in NCBI{$39}s SNP repository dbSNP. The pig whole genome is currently being sequenced with billions of sequences completed. Hundreds of thousands of porcine SNPs are discovered in genome sequence data and expressed sequence tag (EST) collections. High density SNP genotyping assays are designed for porcine genome. Therefore, the extensive applications of porcine SNP are developed, some of which include constructing of genetic linkage map, mapping of quantitative trait loci (QTL), detection of genetic diversity, genome-wide association study.
Key words: pig; SNP; genome wide association study
 
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