中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(4): 364-368
let-7 microRNA调控动物器官发育的研究进展
王 虹,滕鸿琦,施珏平,张彦定,张明凤*
(福建省发育与神经生物学重点实验室,福建师范大学生命科学学院,福州 350108)
摘 要:微小RNA (microRNA, miRNA)是一类在进化上高度保守、长度约 20~24 nt的小分子非编码RNA,能通过与靶基因3′非翻译区相结合从而抑制靶基因的翻译或降解靶基因。let-7 microRNA是发现较早的一类miRNA,最早在线虫中发现能调控细胞分裂的时序。此后大量证据表明,let-7参与动物多个器官发育的调控过程,并与人类疾病发生密切相关。该文综述了近年来let-7调控动物脑、神经及心肺系统等器官发育的研究成果,初步阐述了let-7调控动物器官发育可能的作用机制,以期为深入研究let-7的功能奠定基础。
关键词:microRNA; let-7; 器官发育; 调控机制
 
Progress of  animal organs development regulated by let-7 microRNA
WANG Hong, TENG Hong-Qi, SHI Jue-Ping, ZHANG Yan-Ding, ZHANG Ming-Feng*
(Fujian Key Laboratory of Developmental and Neurobiology, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China)
Abstract: MicroRNAs (miRNAs) are a class of small non-coding RNAs, about 20~24 nucleotides in length. They can inhibit target genes translation or degrade them directly through combination with the complementary sequences in the 3′-UTRs of target mRNAs. The let-7 miRNAs were originally found in the nematode Caenorhabditis elegans, where they mainly regulated the timing of cell division. Increasing evidences indicate that let-7 miRNAs are associated with animal organs development and human diseases. This review summarized the recent progresses about the function of let-7 miRNAs in the development of brain, neuron, lung and cardiovascular system. Meanwhile, we elucidated the possible mechanism of let-7 miRNAs regulating the developmental processes of animal organs that might provide the basis for further illustrating the function of let-7 miRNAs.
Key words: microRNA; let-7; organ development; regulation mechanism
 
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