中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(3): 286-290
IL-23/Th17轴在变应性哮喘中的研究进展
杨 影1,罗 英1*,李春林1,杨春平1,罗 璝1,付明福2,廖新根2
(1 南昌大学第二附属医院耳鼻咽喉-头颈外科,南昌 330006;2 南昌大学第二附属医院骨科,南昌 330006)
摘 要:变应性哮喘是一种由辅助性T细胞 (T helper cell, Th cell)调节的慢性炎症性疾病。Th1/Th2的失衡一直被认为是变应性哮喘的发病机制,Th2细胞及其分泌的细胞因子白介素4(interleukin 4, IL-4)、IL-5以及IL-13在变应性哮喘特异性症状的发病中发挥重要作用。最近研究发现Th17细胞及其分泌的IL-17参与变应性哮喘的发展过程,IL-23在Th17细胞维持生存和功能成熟中发挥重要作用,并参与抗原诱导的气道炎症反应。该文对目前IL-23/Th17轴在变应性气道炎症反应中的研究进展作一综述。
关键词:IL-23;Th17;IL-17;哮喘
 
Recent progress of IL-23/Th17 axis in allergic asthma
YANG Ying1, LUO Ying1*, LI Chun-Lin1, YANG Chun-Ping1, LUO Gui1, FU Ming-Fu2, LIAO Xin-Gen2
(1 Otolaryngology - Head and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; 2 Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China)

Abstract: Allergic asthma is a chronic inflammatory disease regulated by the T helper (Th) cells. The Th1/Th2 imbalance has been well documented in the pathogenesis of allergic asthma, Th2 cells and their cytokines such as interleukin 4 (IL-4), IL-5, and IL-13 orchestrate these pathognomonic features of asthma. Recently, Th17 cells and IL-17 have been found to participate in the development of allergic asthma, IL-23, which is essential for survival and functional maturation of Th17 cells, is involved in antigen-induced airway inflammation. In this review, current understanding of the roles of IL-23/Th17 axis in allergic airway inflammation will be summarized.
Key words: IL-23; Th17; IL-17; asthma
 
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