中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(3): 261-266
人乳头状瘤病毒感染与肺癌关系的研究进展
李 刚, 何 丽, 唐旭东*
(广东医学院生物化学与分子生物学教研室,湛江 524023)
摘 要:近年越来越多的研究发现肺癌组织中有人乳头状瘤病毒(human papillomavirus,HPV)DNA和癌蛋白的检出,其检出率具有地域差异性,但不同地方HPV检出亚型具有高度的一致性,主要是高危型HPV-16和HPV-18。HPV可能主要通过血液循环从宫颈癌病灶等原发部位转移到肺,从而可能诱发肺癌的发生。HPV诱发肺癌的机制可能与影响p53 的失活及端粒酶的激活等有关。
关键词:人乳头状瘤病毒;肺癌;p53;端粒酶
 
Research progress of relationship between human papillomavirus infection
LI Gang, HE Li, TANG Xu-dong*
(Department of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang 524023, China)
Abstract: In recent years, a number of studies showed that HPV-DNA and oncoproteins were detected in lung cancer tissues. The detection rate was from 0 to 80% with the differences of regions, but there was no significant difference between HPV subtypes in lung cancer, and high-risk types HPV -16 and -18 were most frequently at present. HPV infected lung from primary cervical cancer may mainly through blood circulation. The mechanism of HPV-induced lung cancer may be related to inactivation of p53 and activation of telomerase.
Key words: human papillomavirus; lung cancer; p53; telomerase
 
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