中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(1): 7-12
局部黏着斑激酶作为肿瘤治疗靶点的研究进展
张文静1,黄启来1*,华子春1,2*
1澳门科技大学中医药学院和澳门药物及健康应用研究所,澳门; 2 南京大学医药生物技术国家重点实验室,南京210093
摘 要:局部黏着斑激酶(focal adhesion kinase, FAK)是一种非受体型酪氨酸蛋白激酶,是细胞内重要的骨架蛋白与多种信号通路的关键分子。FAK在肿瘤发生、发展、迁移和侵袭的各个阶段都具有重要作用,FAK已经被当作潜在的肿瘤治疗靶点来研究。该综述将对FAK与肿瘤的关系以及FAK作为肿瘤治疗靶点的研究进展进行探讨。
关键词:局部黏着斑激酶;抗肿瘤;治疗
 
Focal adhesion kinase, a novel target for cancer therapy
ZHANG Wen-Jing1, HUANG Qi-Lai1*, HUA Zi-Chun1, 2*
1Faculty of Chinese Medicine and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China; 2The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, Chi
Abstract: Focal adhesion kinase (FAK), a cytoplasmic non-receptor protein tyrosine kinase, serves as both a molecular scaffold and a mediator participating in multiple signal transduction pathways. FAK is involved in tumor cell survival, proliferation, migration and metastasis. Currently, FAK has been regarded as a potential target for cancer therapy. This review is to summarize the relationship between FAK and tumor progression, and to discuss the strategies targeting FAK for cancer treatment.
Key words: focal adhesion kinase; antitumor; treatment
 
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