中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2011, 23(1): 1-6
Akt/PKB抗凋亡机制与天然活性物质的抗肿瘤作用
刘玉梅1,祖桂芳2,赵晓红1*,梅 晶1
1北京联合大学应用文理学院,北京 100191;2 首都师范大学生物科学学院,北京100037
摘 要:Akt/PKB是调控细胞生存与凋亡的重要信号物质之一。它能够影响下游多种效应分子的活化状态,在细胞内发挥着抑制细胞凋亡、促进细胞增殖的作用,并同人类多种肿瘤的发生发展密切相关。天然活性物质能够通过抑制Akt/PKB通路、诱导细胞凋亡来发挥它们的抗肿瘤效应。对Akt/PKB与细胞凋亡关系的研究不但有利于理解细胞凋亡机制,还可以指导开发新型的抗癌活性物质。本文综述了Akt/PKB对细胞凋亡、存活的调节机制及天然活性物质通过PI3K/Akt信号通路抗肿瘤作用的研究进展。
关键词:Akt/PKB;细胞凋亡;信号通路;抗肿瘤;天然活性物质
 
The anti-apoptosis mechanisms of Akt/PKB and anti-tumor effects of natural active substances
LIU Yu-Mei1, ZU Gui-Fang2, ZHAO Xiao-Hong1*, MEI Jing1
1 College of Applied Arts and Sciences, Beijing Union University, Beijing 100191, China; 2 College of Life Science, Capital Normal University, Beijing 100037, China
Abstract: Akt/PKB is one of the important signal molecules, which play a pivotal role in inhibiting apoptosis, promoting proliferation and influencing the activation state of some downstream molecules, and is closely correlated with human tumorigenesis. The anti-tumor effects of natural active substances can be achieved by inhibiting Akt signaling pathway to induce apoptosis. The study of the relationship between Akt/PKB and apoptosis is important, not only for understanding the basic cellular life phenomenon, but also for developing new anticancer active compounds. The mechanisms of Akt/PKB regulation in apoptosis, cell survival and anticancer effects of natural active substances by Akt/PKB signaling pathway were reviewed.
Key words: Akt/PKB;  apoptosis; signal pathway; anticancer; natural active substance
 
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