中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(12): 1241-1246
细胞因子与酒精性肝病
刘丽琼1,2,骆 嘉1,柯尊记1*
(1 中国科学院上海生命科学研究院营养科学研究所,营养与代谢重点实验室,上海200031;

摘 要:酒精性肝病(alcoholic liver disease, ALD)的发生发展过程与体内多种细胞因子有关,尤其是肿瘤坏死因子-a(tumor necrosis factor-a, TNF-a)和转化生长因子-b(transforming growth factor-b, TGF-b)在调节肝细胞的凋亡过程中具有重要作用。TNF-a可引起肝细胞凋亡与炎症反应等,抗TNF-a治疗能明显减轻酒精引起的肝损害; TGF-b具有增加细胞外基质的合成和抑制细胞外基质降解的作用,TGF-b1升高与肝纤维化密切相关。细胞因子可能是防治酒精性肝病的有效分子靶点。
关键词:酒精性肝病;肿瘤坏死因子-a;转化生长因子;炎症反应
中图分类号:R573; R392.32  文献标识码:A


    


 

 
The role of cytokines in the progress of alcoholic liver disease
LIU Li-qiong 1,2, LUO Jia1, KE Zun-Ji 1*
(1 Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; 2 Shanghai University of Traditional Chinese Medicine, Shanghai 20120

Abstract: Cytokines, especially tumor necrosis factor-a (TNF-a) and transforming growth factor-b(TGF-b), play an important role in the mechanisms in the pathogenesis of alcoholic liver disease (ALD), such as steatohepatitis, fibrosis, and cirrhosis. TNF- a and TGF-b are involved in the apoptotic liver cell death. TNF-a also takes part in the inflammation related to ALD. TNF-a antibody can distinctly alleviate alcohol-induced liver injury. TGF-b can increase extracellular matrix synthesis and inhibit its degradation; TGF-b1 is intimately related to the alcoholic liver fibrosis. Cytokines are promising targets for preventing and treatment of the ALD.
Key words: alcoholic liver disease; tumor necrosis factor-a; transforming growth factor; inflammation

 
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