中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(12): 1200-1207
“试管婴儿”技术30年——回顾和展望
林 戈1,2,卢光琇1,2*
(1中南大学生殖与干细胞工程研究所,长沙410078;2中信湘雅生殖与遗传专科医院,长沙410008)

摘 要:1978年第一例试管婴儿诞生以及随后近30多年来该领域不断取得的突破性进展,促进了以体外受精为基础的辅助生殖技术在临床的广泛应用,并取得了很好的疗效。本文将系统回顾近30多年来辅助生殖技术在临床和实验室两方面建立的包括:控制性超排卵、序贯培养、精子胞浆内注射以及植入前遗传学诊断和筛查等主要技术突破,并对医源性多胎、新技术的安全性等目前存在的主要问题及可能的解决方案进行探讨。
关键词:体外受精;控制性超排卵;胚胎培养;精子胞浆内注射;植入前遗传学诊断/筛查;玻璃化冷冻;多胎
中图分类号:Q321+.1 文献标识码:A


    


 

 
30 years of "test-tube" baby?technology: retrospect and prospect
LIN Ge1,2, LU Guangxiu1,2*
(1 Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410078, China; 2 Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha 410008, China)
Abstract: Since the birth of the first "test-tube" baby?in 1978, numerous achievements have been made on assisted reproductive technology (ART) in recent 30 years, which promotes its broad and successful clinical application. Here, we systematically review the important advancements in in vitro fertilization treatment, including controlled ovarian hyperstimulation, sequential embryo culture, intracytoplasmic sperm injection and preimplantation genetic diagnosis and screening, etc. We will also discuss the major challenges nowadays in ART, including multiple gestation, safety issue of newly developed technology. 
Key words: in vitro fertilization; controlled ovarian hrperstimulation; embryo culture; ICSI; PGD/PGS; multiple pregnancy
 
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