中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(11): 1192-1195
多发性骨髓瘤与白细胞介素-6
王建军,洪丽萍,汤立军*
中南大学生物科学与技术学院分子生物学研究中心,长沙410078
摘 要:白细胞介素-6是多发性骨髓瘤(multiple myeloma,MM)瘤细胞生长和生存的关键因子,也是MM患者发病的主要因子。IL-6/IL-6R系统通过不同通路影响多发性骨髓瘤瘤细胞生长并导致患者骨损害、类风湿性关节炎等一系列并发症。针对IL-6/IL-6R系统的治疗方法将给MM的治疗带来重大的进展。
关键词:IL-6/IL-6R;gp130;多发性骨髓瘤
 
Multiple myeloma and interleukin-6
WANG Jian-jun, HONG Li-ping, TANG Li-jun*
Molecular Biology Research Center, Institute of Life Science and Technology, Central South University, Changsha 410078, China
Abstract: Interleukin-6 is a key growth and survival factor, which is involved in tumorigenesis of multiple myeloma. The proliferation of malignant cells in multiple myeloma are affected through different pathways of IL-6/IL-6R ,which also could lead to bone damage, rheumatoid arthritis and some other complications in patients. Treatment of MM targeted IL-6/IL-6R system will provide a new therapeutic approach based on interruption of IL-6 mediated tumor cell growth in future.
Key words: IL-6/IL-6R; gp130; multiple myeloma
 
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