中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2007, 19(1): 63-
p75NTR介导神经细胞凋亡研究进展
刘 宇1,邓宇斌1*,周丽华2
1中山大学中山医学院病理生理学教研室,广州 510080;2中山大学中山医学院解剖教研室,广州 510080
摘 要:在神经发育过程中,神经营养因子通过其低亲和力受体p75NTR与高亲和力受体Trk的介导,在神经元的存活、分化与髓鞘形成中发挥着重要的作用;与存活、生长这些“正性”信号相反,p75NTR也介导受损后及新生神经元凋亡这一“负性”信号。一直以来,p75NTR是如何介导这些截然相反的功能仍不清楚,尤其是何时引起凋亡,其机制如何更是所知甚少。近来,随着s-p75NTR、proNGF、sortilin复合受体等的发现,其中的一些机制开始有所明朗。本文就p75NTR介导神经元凋亡的研究进展做一综述。
关键词:p75NTR;凋亡;神经元
 
Advance in research on the apoptosis of neuronal cells mediated by p75NTR
LIU Yu1, DENG Yubin1*, ZHOU Lihua2
1 Department of Pathophysiology, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510080, China; 2 Department of Anatomy, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510080, China
Abstract: Neurotrophins are essential factors during neuronal development. They promote survival, differentiation and myelination of neurons via Trk receptor tyrosine kinases and the p75 neurotrophin receptor. Paradoxically, compare to these "positive"roles, the p75 neurotrophin receptor also ensures some "negative" roles such as apoptosis of neonatal and injured neurons. Until recently, the mechanisms by which the p75 neurotrophin receptor governs these opposing functions have remained elusive. By the identification of new ligands and cytosolic interacting partners, receptor cleavage products and coreceptors such as: s-p75NTR, proNGF and sortilin, some of these mechanisms are now being unraveled. Here, we review recent progress in delineating the molecular networks that enable p75NTR to dictate neuroal apoptosis.
Key words: p75NTR; apoptosis; neurons
 
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